Kupihwa kwemishonga inyaya yakakomba uye isina kusimba inofanirwa kudzorwa nenyanzvi uye kana zviri zvemhuka hazvina kusiyana. Nguva zhinji munhu anowira mukukanganisa kwekuzvirapa, zvisinei tsika iyi inofanirwa kubviswa uye kushandiswa kwemishonga hakufanirwe kurerutswa.
Dambudziko rezvipukanana mumhuka dzinovaraidza senge imbwa nekatsi rinofanirwa kudzorwa pasina kuregeredza. Kuregeredza dambudziko iri kune zvakakomba mhedzisiro kune zvese mhuka uye varidzi. Mumwe weanoshanda kwazvo mukurwira kurwisa zvipembenene ndeye milbemax Uye zvakakosha kwazvo kuziva kukura kwemushonga uyu.
Ruzivo rwekutanga
Izvo zvakanaka kutevedzera zvirevo zvekurapa uye kuzvizivisa iwe nenzira yakatwasuka Milbemax mushonga kubva kumarabhoritari eNovartis Sanidad Animal SL, ayo ine antiparasite inoshanda chinhu inozivikanwa se milbemycin oxime. Ichi chikamu chinowirirana neboka re macrocyclic lactones, yakasarudzika kubva pakuvira kwe Streptomyces hygroscopicus var Aureolacrimosus y inoshandiswa pakurwisa utachiona hwemukati hwembwa nekatsi. Izvo zvipembenene zvinorwisa ndezvemudumbu nematode honye.
Milbemax inoshanda seye anthelmintic, ndokuti, kurwisa helminth kana hutachiona hutachiona. Kuita kwayo kunokurumidza uye kwakaringana, kungave nekuti kunovabvisa kana nekuti kunovakonzera kuti vabve mumuviri, nokudaro kudzikamisa hutachiona hutachiona pasina kusiya zvinonetsa.
Iwo mafarmacological zvimiro zvemilbemax ari kushingairira kurwisa mite mudhivhirivhiti uye yakakura danho rematodes. Izvo zvinoshandawo padanho remaruva eiyo dirofilaria immitis, mhando yehutachiona iyo inogara iri imbwa.
Iyo yekubereka nhanho inoitika mukati me pulmonary arteri uye kurudyi ventricle yemoyo wembwa. Utachiona uhwu hunogona kurarama kwemakore mazhinji uye hunokonzera canine heartworm, chirwere chakakomba chembwa.
Maitiro Milbemax anoshanda kukonzeresa makemikari shanduko mune metabolism yemuviri wemhuka yakabatwa. Mhonye dzinova nehanya nekushandurwa uku sezvo nharaunda ine hukasha yakagadzirirwa mahairasi. Idzi shanduko, semuenzaniso, iyo inhibition ye mitochondrial fumarate reductase, inoderedza glucose kutakura kana uncouples oxidative phosphorylation.
Basa reichi chinodhaka pane iyo neurotransmission yeinvertebrates, milbemycin oxime, yakafanana neavermectins uye mamwe milbemycins, inowedzera kukwana kweiyo membrane yematode uye zvipembenene kune chloride ions, kuburikidza nekloride ion chiteshi, inodzorwa ne glutamate (inoenderana neGABA uye glycine receptors mune vertebrates).
Izvi zvinokonzera hyperpolarization yeiyo neuromuscular membrane. ine flaccid kuoma mitezo uye inotevera kufa kwehutachiona. Praziquantel inogadzirwa neacyl ye pyrazine-isoquinoline.
Praziquantel inoshanda kurwisa cestode uye trematode, kubvira inogadzirisa kubvumidzwa kwehutachiona hwehutachiona kuva calcium (Ca2 + inoputika) inokonzera kusaenzana muzvikamu zve membrane uye zvinotungamira mukudzikiswa kweiyo membrane uye inodzvanya pakarepo yeiyo musculature (tetany), kudzoreredza nekukurumidza kweiyo syncytial kukanganiswa uye kunotevera kupesana kwekuparadzanisa (kubhabhatidza), uko kunopera kudzingwa kwehutachiona kubva mudumbu rematumbu kana kufa kwayo.
Zvairatidza uye chipimo chemushonga
Kurapa ne milbemax Inoratidzwa mune imbwa dzine hutachiona hwakakanyiwa ne cestode, uye nematodes (Ancylostoma caninum, toxocara canis, Toxascaris leonina, Trichuris vulpis, Crenosome vulpis). Mune yekupedzisira, huwandu hwehutachiona hwaderedzwa. Mushonga uyu unogona zvakare kushandiswa mukudzivirira kweDirofilaria immitis.
Muyero weantiparasitics zvinoenderana nemirau yenyika yega yega. Iko kune kurudziro yemuyero we milbemycin oxime yakaburitswa nevagadziri, yakanyorwa mune yesainzi mabhuku.
Mushonga Inowanzo shandiswa muimbwa dzinorema isingasviki mashanu makirosi uye pasi chete yakaoma veterinary kuongororwa. Iwe unofanirwa kugara uchiverenga chitaridzi nekuti pane misiyano zvichienderana nenyika.
- Imbwa kubva pa0,5 kusvika 1 kg yew bw: 1/2 piritsi imbwa diki.
- Imbwa dzine anopfuura 1 kusvika ku5 kg yew bw: 1 piritsi rembwa diki.
- Imbwa dzine anopfuura mashanu kusvika gumi makirogiramu ebw: Mahwendefa maviri embwa diki.
- Imbwa dzine anopfuura mashanu kusvika makumi maviri makirogiramu ebw: 5 imbwa piritsi.
- Imbwa dzine anopfuura makumi maviri nemashanu kusvika makumi mashanu makirogiramu ebw: 25 mahwendefa embwa.
- Imbwa dzine anopfuura makumi maviri nemashanu kusvika makumi mashanu makirogiramu ebw: 50 mahwendefa embwa.
Chigadzirwa hachifanirwe kushandiswa imbwa pane katsi uye zvinopesana, kana kune mhuka hombe pane mhuka diki. Kune mhando dzembwa dzisingashiviriri milbemycin oxime zvakanaka kana mamwe macrocyclic lactones senge doramectin, ivermectin, moxidectin, selamectin, emodepside, kana imwe isiri-antiparasitic mishonga.
Mune madhiri epamusoro pane kukurudzirwa inogona kuunza zvimwe kana zvishoma zvakakomba kushivirira matambudziko. Ndosaka zvichikosha kuti muyero unofanirwa kuitwa nenzira kwayo.
Mhosva umo kunyatsotarisirwa kunofanirwa kubhadharwa kuri muCollies uye mabhureki anotevera, iyo ine shanduko (mune iyo MDR-1 geni) iyo inobata ropa-brain barriers iyo inodzivirira mimwe mishonga kazhinji kupinda muhuropi hwemammalia.
Pamusoro peCollies, mamwe marudzi akaratidzirawo matambudziko akafanana, akadai saBobtail, Border Collie, Bearded Collie, McNab, Silken Greyhound, Whippet Greyhound, Australian Mufudzi, White Swiss Mufudzi, Chirungu Mufudzi, Shetland Mufudzi, Wäller, kunyangwe iko kuchinja. Inokanganisa haisati yasimbiswa mune ese aya mabheji.
Uchishandisa Milbemax inofanirwa kuteedzera kuisirwa kwakakodzera nzira dzekuongorora dzehutachiona hwakasanganiswa nematatomi uye cezvose, tichifunga nhoroondo uye hunhu hwemhuka, senge zera, hutano, nharaunda (imbwa dzakachengetwa, imbwa dzinovhima), chikafu (kuwana nyama mbishi), nzvimbo nenzvimbo uye mafambiro
Sarudzo yekupa chigadzirwa mune imbwa dziri panjodzi yekusanganiswa zvakare kana mune yakatarwa njodzi inofanirwa kuitwa nachiremba wemhuka anoona. Zviratidzo zvekuchipatara muCollie imbwa zvakafanana neizvo zvinoonekwa muhuwandu hwembwa dzinodarika.
Kurapa imbwa nenhamba yakakura yezvipembenene zvemicrofilarial kunogona kutungamira mukukudziridza kwe hypersensitivity zvakadai semaronda akachenuruka, kurutsa, kudedera, kufema, kana kunyanya mate. Aya maitiro ane chekuita nekuburitswa kwemapuroteni kubva kune akafa kana kufa microfilariae, uye haisi yakananga huturu mhedzisiro yemushonga.
Iko hakuna kuzivikanwa kunoitwa mune dzakanyanya kusimba imbwa kana mune vanhu vane dzakakanganiswa itsvo kana chiropa, nekuti milbemax haina kukurudzirwa mune idzi mhuka kunze kwekunge paine nyanzvi yekuongorora.