Samun magunguna lamari ne mai mahimmanci kuma mai mahimmanci wanda dole ne ƙwararren masani ya sarrafa shi a wajen dabbobi kuwa ba shi da bambanci. Yawancin lokuta mutum yana fadawa cikin kuskuren shan magani, amma duk da haka ya kamata a kawar da wannan aikin kuma bai kamata a raina amfani da magunguna ba.
Dole ne a shawo kan matsalar ƙwayoyin cuta a cikin dabbobi irin su karnuka da kuliyoyi ba tare da wani sakaci ba. Yin watsi da wannan matsalar na da mummunan sakamako ga dabba da masu ita. Daya daga cikin mahimman kawancen yaki da cutar parasites shine milbemax Kuma yana da matukar mahimmanci sanin girman wannan maganin.
Bayani na asali
Manufa ita ce bin dokokin likita da sanar da kanka ta hanyar da ta fi dacewa. Milbemax magani ne daga dakunan gwaje-gwaje na Novartis Sanidad Animal SL, wanda yana dauke da sinadarin antiparasitic mai aiki da aka sani da milbemycin oxime. Wannan mahaɗan na ƙungiyar macrocyclic lactones, keɓe daga keɓaɓɓiyar ferment na Streptomyces hygroscopicus var Aureolacrimosus y ana amfani dashi akan cututtukan cikin gida na karnuka da kuliyoyi. Kwayoyin cutar da ke kai harin su ne tsutsotsi na hanjin ciki.
Milbemax yana aiki azaman anthelmintic, wato, kai hare-hare helminth ko cututtukan tsutsa. Aikinsa yana da sauri kuma daidai, ko dai saboda yana kawar dasu ko kuma saboda yana haifar musu da barin jiki, saboda haka rage nauyin kwayar cutar ba tare da barin rikitarwa ba.
Kayan magani na milbemax suna aiki da ƙwayoyin cuta a cikin larval da balagagge matakin nematodes. Hakanan yana da tasiri a matakin larva na Misalin Dirofilaria, wani nau'in m wanda tabbas yana cikin karnuka.
Matakan haihuwa yana faruwa ne a cikin jijiyoyin huhu da jijiyar dama na zuciyar kare. Wannan m zai iya rayuwa tsawon shekaru kuma yana haifar da cututtukan zuciya na canine, cuta mai tsanani ga karnuka.
Hanyar Milbemax tana aiki shine haifar da sauye-sauyen sinadarai a cikin aiki na kwayoyin dabbar da abin ya shafa. Tsutsotsi suna da hankali ga waɗannan canje-canjen tunda an ƙirƙiri yanayin maƙiya don ƙwayoyin cuta. Waɗannan canje-canje sune, alal misali, hanawa na mitochondrial fumarate reductase, yana rage jigilar glucose ko uncouples oxidative phosphorylation.
Ayyukan wannan magani kan yaduwar kwayar invertebrates, milbemycin oxime, daidai yake da avermectins da sauran milbemycins, yana kara tasirin membrane na nematodes da kwari zuwa ion chloride, ta hanyar tashoshin chloride ion, masu sarrafawa ta hanyar glutamate (masu alaƙa da GABA da masu karɓar glycine a cikin kashin baya).
Wannan yana haifar da hauhawar jini daga membraus. tare da gurɓataccen nakasa da kuma mace-macen da suka biyo baya. Praziquantel wani samfurin acyl ne na pyrazino-isoquinoline.
Praziquantel yana aiki da cestodes da trematodes, tun yana canza ƙarancin membranes na ƙwayoyin cuta zuwa alli (Ca2 + ambaliya) yana haifar da rashin daidaituwa a cikin sassan membrane kuma yana haifar da ɓarkewar membrane da ƙuntataccen hanzari na musculature (tetany), saurin ɓarkewar haɗin aiki tare da haifar da lalacewar ƙananan ƙwayoyin cuta (kumfa), wanda ya ƙare a ciki fitar da kwayar cutar daga jikin mahaifa ko mutuwarsa.
Manuniya da sashi
Jiyya tare da milbemax An nuna shi a cikin karnuka tare da haɗuwa da cututtuka tare da cestodes, da nematodes (Cancyt na ancylostoma, toxocara canis, Toxascaris leonina, Trichuris vulpis, Crenosome vulpis). A karshen, matakin kamuwa da cuta ya ragu. Hakanan za'a iya amfani da wannan maganin a rigakafin cutar Dirofilaria.
Yawan antiparasitics ya dogara da ka'idojin kowace ƙasa. Akwai wasu shawarwari game da samfurin milbemycin oxime da masana'antun suka bayar, wanda aka rubuta a cikin wallafe-wallafen kimiyya.
Maganin Yawanci ana amfani dashi a cikin karnuka masu nauyin kasa da kilo biyar kuma suna ƙasa da ƙasa tsaurara lafiyar dabbobi. Ya kamata koyaushe ku karanta lakabin saboda akwai bambancin dangane da ƙasar.
- Karnuka daga 0,5 zuwa 1 kilogiram na bw: 1/2 ƙaramin ƙananan karnuka.
- Karnuka tare da fiye da kilogiram 1 zuwa 5 na bw: kwamfutar hannu 1 don kananan karnuka.
- Karnuka tare da fiye da kilogiram 5 zuwa 10 na bw: allunan 2 na kananan karnuka.
- Karnuka tare da fiye da kilogiram 5 zuwa 20 na bw: kwamfutar kare 1.
- Karnuka tare da fiye da kilogiram 25 zuwa 50 na bw: allunan kare 2.
- Karnuka tare da fiye da kilogiram 50 zuwa 75 na bw: allunan kare 3.
Kada a taɓa amfani da samfurin don karnuka a kan kuliyoyi kuma akasin haka, ko don manyan dabbobi akan ƙananan dabbobi. Akwai nau'ikan karnukan da basa jure wa milbemycin oxime da kyau ko kuma wasu lactones na macrocyclic kamar su doramectin, ivermectin, moxidectin, selamectin, emodepside, ko wasu magungunan da ba antiparasitic ba.
A cikin allurai mafi girma fiye da shawarar na iya gabatar da ƙari ko ƙananan matsalolin haƙuri. Wannan shine dalilin da ya sa yana da mahimmanci a yi sashi daidai yadda ya kamata.
Shari'o'in da kulawa ta musamman ya kamata a biya suna cikin Collies da kiwo na gaba, wanda ke da maye gurbi (a cikin kwayar halittar MDR-1) wanda ke shafar katangar kwakwalwar jini wanda ke hana wasu magunguna yawanci shiga cikin kwakwalwar mahaifa.
Baya ga Collies, sauran nau'ikan sun nuna irin wannan matsalolin, kamar su Bobtail, Border Collie, Bearded Collie, McNab, Silken Greyhound, Whippet Greyhound, Australian Shepherd, White Swiss Shepherd, Ingilishi Makiyayi, Shetland Shepherd, Wäller, kodayake maye gurbin Har yanzu ba a tabbatar da lahani ba a cikin waɗannan nau'ikan.
Amfani da Milbemax yakamata a bi aiwatar da matakan bincike masu dacewa don cakuda cututtuka ta hanyar nematodes da ceduka, la'akari da tarihi da halaye irin na dabba, kamar shekaru, lafiya, muhalli (karnukan da aka killace, karnukan farauta), abinci (samun danyen nama), yanayin kasa da motsi.
Shawarwarin gudanar da samfurin a cikin karnukan da ke cikin haɗarin haɗuwa ko kuma a cikin yanayi na haɗari dole ne likitan dabbobi ya yanke hukunci. Alamun asibiti a cikin karnukan Collie sun yi kama da waɗanda ake gani a cikin yawancin karnukan da ke wuce gona da iri.
Jiyya na karnuka tare da adadi mai yawa na cututtukan microfilarial na iya haifar da ci gaba da kumburi kamar kodadden lakar jikin mutum, amai, rawar jiki, rashin numfashi, ko yawan jin gishiri. Wadannan halayen suna da alaƙa da sakin sunadarai daga matacce ko microfilariae mai mutuwa, kuma ba tasiri mai guba kai tsaye na magani ba.
Babu wani sanannen karatu a cikin karnukan da suka raunana sosai ko kuma a cikin daidaikun mutane masu cutar koda da hanta, saboda ba a ba da shawarar milbemax a cikin wadannan dabbobin sai dai idan akwai kwararrun kima.